Table 1. List of antimalaria protein target, docking center coordinate, root mean square deviation (RMSD), and role of protein in Plasmodium falciparum

Protein (PDB ID)	Center coordinate			RMSD (Å)	Role in antimalaria activity	References
	X	Y	Z
Lactate dehydrogenase (1ldg)	25.329	23.422	41.843	1.2875	Relating to the anaerobic nature of parasite life	Dunn et al. (1996)
M1 Alanylaminopeptidase (3ebh)	14.248	11.055	12.141	1.4307	Involved in the terminal stages of hemoglobin digestion and essential for the provision of amino acids used for parasite growth and development within the erythrocyte.	McGowan et al. (2009)
Plasmepsin II (5yib)	18.733	−25.663	−24.032	1.9086	Inhibition plasmepsin protein correlated with hemoglobin catabolism in which parasite survival was depended on host haemoglobin consumption	Mishra et al. (2018)
PfNDH2 (5jwc)	29.304	10.210	25.414	1.4617	Inhibition of PfNDH2 will inhibit the reaction of ubiquinol formation, which will interfere with the parasite’s respiratory system	Yang et al. (2017)
Falcylisin (8ho4)	−32.065	5.463	−11.464	0.7339	Inhibition of falcylisin disrupt the short polypeptide cleavage process, resulted accumulation of short poplypeptide in organel	Lin et al. (2024); Wirjanata et al. (2024)